Product Specifications: Lyophilized Powder (>99% purity) in 3ml vial. *Requires Reconstitution ** Available for bulk custom order with 57 Cap/Crimp colors to choose from.
Application: Research peptide evaluated in immune system regulation, metabolic disorder, gastrointestinal disorders, cancer treatment, cardiovascular improvement, neurological treatment, anti-inflamation.
Chemical Formula: C147H237N43O43S
CAS Number: 40077-57-4
Molecular Weight: ~3325.8 g/mol
Concentration: ≥99%
Vasoactive Intestinal Peptide (VIP) is a 28-amino-acid peptide that serves as a neurohormone and neurotransmitter in the human body. This bioactive molecule has attracted significant scientific interest due to its diverse physiological functions and potential therapeutic applications. This report presents a comprehensive overview of the current research directions involving VIP peptide.
Molecular Characteristics and Basic Function
VIP is a hydrophilic peptide involved in multiple physiological actions such as vasodilation, bronchodilation, cell division, and neuroprotection. As a naturally occurring neuropeptide, it functions primarily as a neurotransmitter but has broad effects throughout multiple body systems. The peptide exerts its physiological effects by binding to specific receptors, notably VPAC1 and VPAC2 receptors.
Therapeutic Research Applications
1. Inflammatory Diseases
VIP has demonstrated significant anti-inflammatory properties, making it a promising candidate for treating various inflammatory conditions:
- Asthma and Respiratory Disorders: VIP's bronchodilatory and anti-inflammatory effects show potential for respiratory conditions.
- Arthritis: Research suggests VIP may help reduce joint inflammation.
- Inflammatory Bowel Disease (IBD): VIP has therapeutic potential for inflammatory disorders of the gut.
- Inflammation-Induced Osteolysis: VIP and its derivatives are being studied for preventing bone loss around dental and orthopedic implants. The peptide shows promise in countering both aseptic and infection-related bone destruction.
2. Neurological Disorders
VIP exhibits neuroprotective effects that are being investigated for several neurological conditions:
- Parkinson's Disease: Research explores VIP's potential to protect dopaminergic neurons.
- Alzheimer's Disease: VIP's neuroprotective properties may help slow neurodegeneration.
- Multiple Sclerosis: The peptide's immunomodulatory and neuroprotective effects could benefit MS patients.
3. Cancer Treatment
VIP shows potential in oncology applications:
- Tumor Growth Inhibition: Studies have demonstrated VIP's ability to inhibit tumor growth in certain cancer types.
- Apoptosis Induction: VIP can induce programmed cell death in specific cancer cells.
- Immunotherapy Enhancement: Recent research (2024) focuses on developing antagonists to VIP receptors to overcome immunosuppressive tumor microenvironments in pancreatic cancer.
- T-Cell Anti-tumor Activity: Peptide antagonists of VIP/VIP receptor signaling have demonstrated increased T-cell anti-tumor activity in experimental models.
4. Cardiovascular Applications
VIP research extends to cardiovascular health:
- Blood Pressure Regulation: VIP may help regulate blood pressure.
- Improved Cardiovascular Function: The peptide shows potential to enhance overall cardiovascular health.
- Biomarker Development: Recent research (2024) indicates that serum VIP levels could serve as a biomarker for atrial fibrillation, potentially helping detect low-voltage areas in patients.
5. Gastrointestinal Disorders
Given its original discovery in intestinal tissue, VIP has significant applications in gastroenterology:
- Irritable Bowel Syndrome (IBS): VIP modulation may help manage IBS symptoms.
- Inflammatory Bowel Disease (IBD): VIP's anti-inflammatory properties show promise for conditions like Crohn's disease and ulcerative colitis.
- Intestinal Regeneration: VIP prominently governs intestinal homeostasis by regulating epithelial progenitor cell proliferation and differentiation.
- Intestinal Motility Regulation: Recent research has identified novel neuroimmune mechanisms by which gut microbiota regulates intestinal motility through VIP, potentially leading to new treatments.
6. Immune System Regulation
VIP exhibits important immunomodulatory properties:
- Autoimmune Disease Management: VIP helps modulate immune responses, showing potential for treating autoimmune conditions.
- Infection Prevention: The peptide's immune-regulating properties may help prevent certain infections.
- Anti-inflammatory Effects: VIP has been identified as an anti-inflammatory neuropeptide with potential antimicrobial properties.
7. Metabolic Disorders
VIP shows promise in managing metabolic conditions:
- Type 2 Diabetes: VIP can stimulate glucose-dependent insulin secretion, particularly by binding to VPAC2 receptors. This makes it a potential therapeutic agent for diabetes management.
8. COVID-19 Therapy
The pandemic sparked interest in VIP's application for COVID-19:
- Cytokine Storm Prevention: VIP is known for its immune-modulating effects by suppressing the release of pro-inflammatory cytokines. which could help prevent severe COVID-19 complications.
- Anti-inflammatory Support: VIP's anti-inflammatory properties could help manage respiratory inflammation associated with COVID-19.
9. Ophthalmologic Applications
Recent research explores VIP's role in eye health:
- Eye Disorders: 2024 research is examining the role of VIP and related neuropeptides in various eye conditions.
References:
Said, S. I., & Mutt, V. (1970). Polypeptide with broad biological activity: Isolation from small intestine. Science, 169(3945), 1217-1218. https://doi.org/10.1126/science.169.3945.1217
Gomariz, R. P., Juarranz, Y., Abad, C., Arranz, A., Leceta, J., & Martínez, C. (2006). VIP-PACAP system in immunity: New insights for multitarget therapy. Annals of the New York Academy of Sciences, 1070, 51-74. https://doi.org/10.1196/annals.1317.006
Delgado, M., & Ganea, D. (2013). Vasoactive intestinal peptide: A neuropeptide with pleiotropic actions in immunity. Neuroimmunomodulation, 20(2-3), 131-140. https://doi.org/10.1159/000345235
Disclaimer: This product is intended solely for laboratory research purposes. It is not suitable for consumption by humans, nor for medical, veterinary, or household purposes. Researchers should handle all peptides with care and adhere to strict safety guidelines during experiments. Only qualified professionals with appropriate expertise should manage and handle this product. The distributor, manufacturer, and seller of this product are not responsible for misuse or any resulting consequences. By accessing this product, you consent to comply with these terms and conditions.
