Product Specifications: Lyophilized Powder (>99% purity) in 3ml vial. *Requires Reconstitution ** Available for bulk custom order with 57 Cap/Crimp colors to choose from.
Application: Research peptide evaluated in wound healing, tissue repair, muscle growth and recovery, neurological repair, cardiovascular health, anti-aging, regenerative medicine, hair growth, diabetes, MS.
Chemical Formula: C38H68N10O14
CAS Number: 885340-08-9
Molecular Weight: ~889.01 g/mol
Concentration: ≥99%
TB500 is a synthetic peptide that replicates the effects of the endogenous Thymosin Beta-4 protein. It is considered the main G-actin sequestering peptide in mammalian tissues and is found in all tissues and cell types except red blood cells. The World Anti-Doping Agency (WADA) has identified the active content of TB500 as the N-terminal acetylated 17-23 fragment of thymosin beta-4 (Ac-LKKTETQ).
As a multifunctional peptide, Thymosin Beta-4 plays a vital role in the repair and regeneration of injured cells and tissues. Its synthetic form, TB500, has been primarily researched for its potential in tissue repair, wound healing, and anti-inflammatory properties.
Primary Research Applications
1. Wound Healing and Tissue Repair
One of the most extensively researched applications of TB500 is its role in wound healing and tissue repair:
- It accelerates wound healing processes by enhancing cell migration to injury sites
- Promotes tissue repair in damaged muscles, tendons, ligaments, and skin
- Reduces scar tissue formation during healing
- Shows efficacy in treating pressure ulcers and venous stasis ulcers
- Improves dermal wound repair in diabetic mice and aged animals
The mechanism behind these effects involves TB500's ability to up-regulate actin, form a ternary complex with actin and profilin, increase cells involved in healing, improve cell migration to injury sites, and promote matrix metalloproteinase expression during wound repair.
2. Cardiovascular Health
TB500 shows promising cardioprotective effects that have gained significant research attention:
- Provides cardioprotection, especially post-myocardial infarction (heart attack)
- Improves cardiac function through reduction of inflammation
- Promotes blood vessel repair and angiogenesis (formation of new blood vessels)
- May help repair blood vessels and improve circulation, reducing strain on the cardiovascular system
These cardiovascular benefits make TB500 a candidate for research in heart attack recovery and various cardiovascular conditions.
3. Neurological Applications
Research into TB500's neurological applications explores its potential to treat various neurological disorders:
- Treatment of neurological disorders including stroke, traumatic brain injury (TBI), and neurodegenerative diseases
- Reduces neuroinflammation and microglial inflammation
- Supports recovery from spinal cord injuries
- Shows potential for multiple sclerosis treatment
- Provides concussion support (often used in conjunction with another peptide, BPC-157)
TB500's ability to "remind" adult organs of their embryonic state makes it particularly interesting for neurological regenerative therapies.
4. Musculoskeletal Health
TB500 has shown significant potential for enhancing musculoskeletal health:
- Enhances muscle growth, strength, and recovery
- Effectively repairs tendons, ligaments, and muscles
- Treats sports and athletic injuries
- Improves joint flexibility and range of motion
The World Anti-Doping Agency has noted TB500's claimed ability to increase muscle growth and tissue repair in horses and other mammals, which has led to monitoring its use in sports.
5. Anti-Aging and Regenerative Medicine
In the field of anti-aging and regenerative medicine, TB500 is being researched for:
- Promoting cell survival and reducing inflammation
- Improving tissue function through enhanced repair mechanisms
- Potentially "reminding" adult organs of their embryonic state to enhance regeneration capabilities
- Up-regulating actin, an important cellular structural protein essential to cell function
These properties make TB500 a compound of interest in anti-aging research, particularly for its potential to enhance the body's natural regenerative processes.
Secondary Research Applications
1. Immunological Applications
TB500 shows promise in supporting immune function:
- Provides immune support (as monotherapy or with Thymosin alpha-1)
- Improves T-cell function
- Has potential applications in sepsis treatment
2. Ophthalmic Applications
Research into TB500's effects on eye health explores:
- Corneal wound healing and repair
- Supporting corneal transplants
- Treatment for diabetic retinopathy
- Management of dry eye disorders and other ocular tissue injuries
3. Additional Applications
Several other areas of TB500 research include:
- Hair growth promotion
- Treatment of chemical burns
- Management of diabetes complications
- Non-alcoholic fatty liver disease (NAFLD)
- Reduction of lung inflammation and fibrosis
References:
Ho, E. N., Kwok, W. H., Lau, M. Y., Wong, A. S., Wan, T. S., Lam, K. K., & Stewart, B. D. (2012). Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma by liquid chromatography-mass spectrometry. Journal of Chromatography A, 1265, 57-69,
Van Eenoo, P. (2013). Investigation of in vitro/ex vivo TB-500 metabolism, synthesis of relevant metabolites and detection limits in urine and plasma. World Anti-Doping Agency Research Project.
Wang, J., Li, Y., Wang, X., Chen, D., Wu, X., Zhang, J., Li, Z., Wang, K., Wang, W., Zhang, J., Wu, G., & Zhang, X. (2024). Simultaneous quantification of TB-500 and its metabolites in in-vitro experiments and rats by UHPLC-Q-Exactive orbitrap MS/MS and their screening by wound healing activities in-vitro. Journal of Chromatography B, 1235, 124033.
Disclaimer: This product is intended solely for laboratory research purposes. It is not suitable for consumption by humans, nor for medical, veterinary, or household purposes. Researchers should handle all peptides with care and adhere to strict safety guidelines during experiments. Only qualified professionals with appropriate expertise should manage and handle this product. The distributor, manufacturer, and seller of this product are not responsible for misuse or any resulting consequences. By accessing this product, you consent to comply with these terms and conditions.
