Product Specifications: Lyophilized Powder (>99% purity) in 3ml vial. *Requires Reconstitution ** Available for bulk custom order with 57 Cap/Crimp colors to choose from.
Application: Research peptide evaluated in wrinkle reduction, collagen production, and cosmetics.
Chemical Formula: C41H70N16O16S
CAS Number: 868844-74-0
Molecular Weight: ~1075.2 g/mol
Concentration: ≥99%
SNAP-8 is a synthetic peptide that has gained significant attention in scientific research for its diverse applications. Also known as acetyl octapeptide-3 or acetyl hexapeptide-8 (AH8), SNAP-8 is a fragment of the SNAP-25 protein, which plays a crucial role in the regulation of neurotransmitter release.
Structure and Chemical Properties
SNAP-8 represents the N-terminus of SNAP-25 protein. It functions as a competitive SNAP25 inhibitor, affecting neurotransmitter release mechanisms. Research indicates that SNAP-8 is more stable than botulinum toxin and more effective than acetyl hexapeptide-3 (Argireline), another peptide used in similar applications.
Research Applications
1. Anti-aging and Cosmetic Applications
The most extensively researched application of SNAP-8 is in the field of cosmetics and anti-aging treatments. SNAP-8 is being studied for:
1.1 Wrinkle Reduction
SNAP-8 has shown promising results in reducing the depth of wrinkles on the face caused by facial expressions, particularly in the forehead and around eyes. Clinical studies have demonstrated SNAP-8's effectiveness in this area:
- A 28-day study found that SNAP-8 reduced wrinkle depth by up to 38% when applied twice daily
- Research suggests that 10% SNAP-8 solution can achieve a maximum wrinkle reduction of up to 63%, significantly outperforming Argireline, which showed only a 27% reduction
1.2 Alternative to Botulinum Toxin
SNAP-8 is actively researched as a non-invasive alternative to Botox treatments. Unlike Botox, which requires injection, SNAP-8 can be applied topically, making it a potentially safer and more convenient option for consumers.
1.3 Muscle Relaxation
Research indicates that SNAP-8 can reduce muscle contraction and relax facial muscles, particularly targeting the superficial muscle cells just under the skin. This mechanism is fundamental to its anti-wrinkle effects.
1.4 Collagen Production
Studies suggest that SNAP-8 may help improve skin elasticity by increasing collagen production and reducing collagen breakdown. This property contributes to its overall anti-aging effects.
2. Therapeutic Applications
Beyond cosmetics, SNAP-8 is being investigated for potential therapeutic uses:
2.1 Blepharospasm Treatment
Clinical trials have explored the safety and efficacy of topical Acetyl Hexapeptide-8 (AH8) as a potential new therapy in blepharospasm (BSP), a condition characterized by involuntary eye muscle contractions. The research specifically targeted the effect of SNAP-8 on the palpebral portion of the orbicularis oculi muscle.
2.2 Neurotransmitter Dysfunction
Due to its mechanism as a SNAP25 inhibitor, researchers are examining SNAP-8's potential applications in treating various conditions related to neurotransmitter dysfunction and muscle activity.
2.3 Anti-inflammatory and Antioxidant Properties
SNAP-8 has demonstrated antioxidant and anti-inflammatory properties, which are being studied for potential therapeutic benefits for skin health beyond mere cosmetic improvements.
3. Mechanistic Research
Scientists are using SNAP-8 to understand fundamental biological processes:
3.1 Neurotransmitter Release Mechanisms
As a competitive SNAP25 inhibitor, SNAP-8 is valuable in studying the mechanisms of neurotransmitter release 1. Research has shown that SNAP-8 inhibits secretory vesicle docking in chromaffin cells, providing insights into neural signaling processes.
3.2 Cellular Signaling Pathways
SNAP-8 is being used in research settings to study neuromodulation, oxidative stress, and cellular signaling, offering insights into protein-protein interactions.
Clinical Evidence and Efficacy
Clinical research on SNAP-8 has shown promising results, particularly in cosmetic applications. Studies suggest:
- Significant wrinkle reduction compared to placebo and other peptides like Argireline
- Good safety profile when applied topically
- Effectiveness at concentrations around 10% for cosmetic applications
However, researchers note that for some applications, such as the treatment of blepharospasm, the optimal concentration may need further investigation, as the concentration used in cosmetic applications may not be sufficient for deeper muscle effects.
References:
Blanes-Mira, C., Clemente, J., Jodas, G., Gil, A., Fernández-Ballester, G., Ponsati, B., ... & Pérez-Payá, E. (2002). A synthetic hexapeptide (Argireline) with anti-wrinkle activity. International Journal of Cosmetic Science, 24(5), 303-310. https://doi.org/10.1046/j.1467-2494.2002.00153.x
Wang, Y., & Wang, M. (2018). SNAP-8: A novel peptide for skin care. Journal of Cosmetic Dermatology, 17(2), 148-153. https://doi.org/10.1111/jocd.12444
Lee, J., & Kim, Y. S. (2020). Efficacy and safety of SNAP-8 in reducing facial wrinkles: A randomized, double-blind, placebo-controlled trial. Journal of Clinical and Aesthetic Dermatology, 13(10), 14–16.
Disclaimer: This product is intended solely for laboratory research purposes. It is not suitable for consumption by humans, nor for medical, veterinary, or household purposes. Researchers should handle all peptides with care and adhere to strict safety guidelines during experiments. Only qualified professionals with appropriate expertise should manage and handle this product. The distributor, manufacturer, and seller of this product are not responsible for misuse or any resulting consequences. By accessing this product, you consent to comply with these terms and conditions.
