Product Specifications: Lyophilized Powder (>99% purity) in 3ml vial. *Requires Reconstitution ** Available for bulk custom order with 57 Cap/Crimp colors to choose from.
Application: Research peptide studied for muscle growth and repair, skin rejuvenation, hair growth, tissue engineering, healing, neuroprotection, cancer treatments.
Chemical Formula: C121H200N42O39
CAS Number: 108174-48-7
Molecular Weight: ~2867.2 g/mol
Concentration: ≥99%
PEG-MGF is a synthetic peptide that combines mechano growth factor (MGF) with polyethylene glycol (PEG). The PEGylation process enhances the peptide's stability, bioavailability, and resistance to enzymatic degradation, potentially increasing its therapeutic efficacy and duration of action. This engineered molecule has attracted significant research interest across multiple medical disciplines.
Primary Research Applications
- Muscle Growth and Repair
PEG-MGF is extensively researched for its potential to stimulate muscle cell proliferation and differentiation. The peptide shows promise for treating various muscle-related disorders by:
- Activating satellite cells in muscle tissue
- Promoting protein synthesis
- Enhancing recovery after muscle damage
- Potentially addressing conditions like sarcopenia and muscular dystrophies
- Tissue Engineering
Researchers are exploring PEG-MGF's applications in tissue engineering due to its ability to promote cell growth and differentiation. Key research areas include:
- Development of functional tissues and organs for transplantation
- Creation of tissue scaffolds with enhanced regenerative properties
- Improving integration of engineered tissues with host systems
- Wound Healing
PEG-MGF is being studied for its potential to enhance wound healing processes through:
- Accelerating cellular migration to wound sites
- Promoting angiogenesis (formation of new blood vessels)
- Enhancing extracellular matrix production
- Potentially addressing chronic wounds and difficult-to-heal injuries
- Neuroprotection
Research suggests PEG-MGF may have significant neuroprotective effects, making it a candidate for treating neurodegenerative diseases by:
- Protecting neurons from damage and death
- Promoting neural cell regeneration
- Potentially mitigating symptoms in conditions like Alzheimer's, Parkinson's, and other neurodegenerative disorders
- Cancer Treatment
PEG-MGF is being investigated for potential anti-cancer applications, including:
- Inhibition of tumor growth
- Induction of apoptosis (programmed cell death) in cancer cells
- Potential adjunct therapy alongside conventional cancer treatments
Secondary Research Applications
- Cosmetic Applications
The regenerative properties of PEG-MGF have attracted interest in cosmetic research:
- Skin rejuvenation treatments
- Hair growth promotion
- Anti-aging formulations
- Sports Medicine
PEG-MGF's muscle-related effects make it relevant to sports medicine research:
- Treatment of muscle injuries
- Enhancement of athletic performance and recovery
- Prevention of muscle atrophy during periods of inactivity
Mechanism of Action
PEG-MGF's therapeutic effects stem from its ability to:
- Interact with specific cell surface receptors
- Activate intracellular signaling cascades
- Stimulate cell proliferation and differentiation
- Modulate inflammatory responses
- Promote tissue regeneration
The PEGylation process extends the peptide's half-life in circulation, allowing for potentially greater therapeutic efficacy compared to unmodified MGF.
References:
Kamal, A., & Thakur, S. (2018). Pegylation of proteins and peptides: A review of the current status. Journal of Pharmacy and Pharmacology, 70(8), 1038-1053. https://doi.org/10.1111/jphp.12953
Lee, S. J., & Lee, B. P. (2017). Mechano-growth factor (MGF) and its role in muscle regeneration. Journal of Exercise Rehabilitation, 13(3), 249-256. https://doi.org/10.12965/jer.1732824.428
Kim, J., & Lee, Y. (2020). Pegylated mechano-growth factor (PEG-MGF) promotes muscle regeneration and improves muscle function in a mouse model of muscular dystrophy. Journal of Controlled Release, 321, 241-253. https://doi.org/10.1016/j.jconrel.2020.02.026
Disclaimer: This product is intended solely for laboratory research purposes. It is not suitable for consumption by humans, nor for medical, veterinary, or household purposes. Researchers should handle all peptides with care and adhere to strict safety guidelines during experiments. Only qualified professionals with appropriate expertise should manage and handle this product. The distributor, manufacturer, and seller of this product are not responsible for misuse or any resulting consequences. By accessing this product, you consent to comply with these terms and conditions.