Product Specifications: Lyophilized Powder (>99% purity) in 3ml vial. *Requires Reconstitution ** Available for bulk custom order with 57 Cap/Crimp colors to choose from.
Application: Research peptide studied for anti-aging, longevity, neuroregeneration, cognitive enhancement, anti-anxiety, stress reduction, mood enhancement, cardiovascular health.
Chemical Formula: C39H54N10O10S
CAS Number: 2920938-90-3
Molecular Weight: ~854.9 g/mol
Concentration: ≥99%
NA Semax Amidate is an acetylated form of the nootropic peptide Semax, which was developed to be pharmacokinetically more stable and increasingly resistant to enzymatic degradation. The peptide shares a seven-amino-acid sequence with Semax, containing a portion of adrenocorticotropic hormone (ACTH 4–7, or Met–Glu–His—Phe) fused with a Pro–Gly–Pro extension at the C-terminus.
What distinguishes NA Semax Amidate from the original Semax is its unique structural modifications:
- Acetic acid at the N-terminus (acetylation)
- Amidation at the C-terminus
These modifications protect the N- and C-termini from hydrolysis and degradation caused by leucine aminopeptidase, resulting in greater stability in brain tissue and prolonged effects. Research suggests that NA Semax Amidate may remain active in the body up to 30 minutes longer than the original Semax before being degraded in blood plasma.
Research Applications
Research into NA Semax Amidate encompasses several potential therapeutic applications:
1. Cognitive Enhancement
As a nootropic peptide, NA Semax Amidate is being extensively studied for its ability to improve cognitive function, memory, and learning. Specific research areas include:
- Mental Fatigue Reduction: Studies on Semax, which provide insights into NA Semax Amidate's potential effects, have shown that the peptide can improve cognitive function in fatigued subjects. One study found that participants who received Semax achieved 71% accuracy on a memory test compared to 41% accuracy for the control group.
- Brain Activity Optimization: Research using functional magnetic resonance imaging (fMRI) has demonstrated that Semax increases volume in the rostral subcomponent of the Default Mode Network (DMN), particularly in the medial frontal cortex. This may indicate improved information processing and episodic memory capabilities.
The enhanced stability of NA Semax Amidate suggests it may deliver these cognitive benefits with greater efficacy and duration than standard Semax.
2. Neuroprotection
NA Semax Amidate demonstrates significant potential as a neuroprotective agent in various contexts:
- Stroke Recovery: Research on Semax, which may be extrapolated to NA Semax Amidate, has shown increased BDNF (brain-derived neurotrophic factor) levels and enhanced motor function in stroke patients. One study involving 110 stroke patients who received Semax for 10 days showed significant improvements in recovery.
- Neurodegenerative Disease Prevention: The peptide is being investigated for its potential to prevent or treat neurodegenerative conditions such as Alzheimer's and Parkinson's diseases.
- Nerve Injury Protection: Research suggests that Semax may help mitigate glaucoma by reducing pressure-driven nerve damage, a property that NA Semax Amidate may share.
- Neurotoxin Protection: Animal models exposed to Semax during alcohol delirium demonstrated increased resistance to the potential neurotoxic effects of ethanol exposure.
These neuroprotective effects are believed to be mediated through NA Semax Amidate's ability to increase neurotrophic factors like BDNF (by approximately 40%) and nerve growth factor (NGF). Research indicates the peptide may potentially increase the brain's tropomyosin receptor kinase B (TrkB) receptor expression by up to 100%, which mediates many of BDNF's neuroprotective effects.
3. Anxiety and Stress Reduction
NA Semax Amidate is being investigated for its anxiolytic properties.
- Studies have shown that while Semax may not noticeably affect anxiety levels under normal conditions, it effectively counters behavioral disturbances triggered by substances that mimic anxiety disorders.
- User reports suggest that NA Semax Amidate may actually brighten mood while producing calming effects, in contrast to NA Semax (without amidation) which some users report can cause edginess.
The peptide's potential anxiolytic effects may be related to its modulation of serotonin, dopamine, and enkephalin signaling, which regulate mood, stress, cognition, and reward-related behavior.
4. Mood Regulation
NA Semax Amidate's potential for mood regulation makes it a candidate for treating depression and other mood disorders:
- The peptide is believed to interact with key neurotransmitter systems involved in mood regulation, including serotonin, dopamine, and enkephalin.
- Its ability to increase BDNF levels may also contribute to its potential antidepressant effects, as BDNF deficiency has been linked to depression.
- Research suggests that NA Semax Amidate may have more pleasant mood effects compared to regular NA Semax, with users reporting that it "brightens mood while calming".
5. Cardiovascular Health
Some research suggests that NA Semax Amidate may have beneficial effects on cardiovascular health, including:
- Potential reduction in blood pressure
- Improvement in cardiac function
These cardiovascular benefits are likely related to the peptide's effects on blood flow regulation, microcirculation, and vascular permeability, which have been observed in studies of Semax.
6. Peptic Ulcer Treatment
An unexpected area of research for NA Semax Amidate is its potential anti-ulcer effects:
- Studies on Semax have shown that peptic ulcers exposed to the peptide healed three times faster than those in a control group (90% vs. 30% healing rate).
- Researchers hypothesize that NA Semax Amidate may accelerate peptic ulcer healing by regulating gastrointestinal blood flow, enhancing microcirculation, and improving vascular permeability.
This application appears unrelated to the peptide's nootropic effects and represents a distinct therapeutic potential.
Mechanisms of Action
The research applications of NA Semax Amidate are supported by several proposed mechanisms of action:
- Neurotrophic Factor Stimulation: The peptide increases levels of brain-derived neurotrophic factor (BDNF) by approximately 40% and nerve growth factor (NGF), which promote neuronal survival, neurogenesis, and brain plasticity.
- Receptor Expression Enhancement: Studies indicate that the peptide may increase expression of TrkB receptors in the brain by up to 100%, which mediate many of BDNF's neuroprotective effects.
- Neurotransmitter Modulation: NA Semax Amidate appears to modulate hormone secretion, stress response, and cognitive processes by influencing serotonin, dopamine, and enkephalin signaling.
- Blood Flow Regulation: The peptide may regulate blood flow, microcirculation, and vascular permeability in various tissues, including the gastrointestinal tract and brain.
- Blood-Brain Barrier Penetration: The peptide's structure allows it to effectively cross the blood-brain barrier, with NA Semax Amidate potentially crossing more efficiently than the original Semax due to its structural modifications.
References:
Kolomin, T., Shadrina, M., Slominsky, P., Limborska, S., & Myasoedov, N. (2013). A new generation of drugs: Synthetic peptides based on natural regulatory peptides. Neuroscience and Medicine, 4(4), 223-252. https://doi.org/10.4236/nm.2013.44035
Vyunova, T. V., Andreeva, L., Shevchenko, K., & Myasoedov, N. (2018). Peptide-based anxiolytics: The molecular aspects of heptapeptide Selank biological activity. Protein and Peptide Letters, 25(10), 914-923. https://doi.org/10.2174/0929866525666180925144642
Inozemtseva, L. S., Karpenko, E. A., Dolotov, O. V., Levitskaya, N. G., Kamensky, A. A., Andreeva, L. A., & Grivennikov, I. A. (2008). Intranasal administration of the peptide Semax regulates BDNF expression in the rat hippocampus in vivo. Doklady Biological Sciences, 421, 241-243. https://doi.org/10.1134/s0012496608040066
Disclaimer: This product is intended solely for laboratory research purposes. It is not suitable for consumption by humans, nor for medical, veterinary, or household purposes. Researchers should handle all peptides with care and adhere to strict safety guidelines during experiments. Only qualified professionals with appropriate expertise should manage and handle this product. The distributor, manufacturer, and seller of this product are not responsible for misuse or any resulting consequences. By accessing this product, you consent to comply with these terms and conditions.
