Product Specifications: Lyophilized Powder (>99% purity) in 3ml vial. *Requires Reconstitution ** Available for bulk custom order with 57 Cap/Crimp colors to choose from.
Application: Research peptide studied for anti-aging, longevity, cognitive enhancement, and anti-anxiety.
Chemical Formula: C33H57N11O9
CAS Number: 129954-34-3
Molecular Weight: ~751.9 g/mol
Concentration: ≥99%
NA Selank Amidate is a heptapeptide and synthetic analog of the endogenous human tetrapeptide tuftsin. It features specific modifications from the original Selank peptide:
- An acetyl group attached to the N-terminus
- An amide group attached to the C-terminus
- A Pro-Gly-Pro fragment to enhance blood-brain barrier penetration
These modifications are designed to protect the peptide from enzymatic breakdown and increase its stability in the body, potentially enhancing its therapeutic effects 1. The chemical structure (Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH2) allows it to effectively pass through the blood-brain barrier and exert effects on the central nervous system.
Primary Research Applications
1. Anxiety Reduction
One of the primary research focuses for NA Selank Amidate is its potential anxiolytic (anxiety-reducing) effects. Research suggests that the peptide interacts with GABA signaling pathways in the brain, potentially producing anti-anxiety effects similar to benzodiazepines but without many of the associated side effects. Clinical studies on Selank, the parent compound, have shown promising results in treating generalized anxiety disorder (GAD), and researchers are investigating whether NA Selank Amidate might offer similar or enhanced benefits.
2. Cognitive Enhancement
NA Selank Amidate is being researched extensively for its nootropic properties—its potential ability to enhance cognitive function. Studies suggest it may:
- Improve memory retention and formation
- Enhance learning capabilities
- Increase focus and attention span
- Protect cognitive function under stress conditions
The cognitive enhancement properties are believed to be related to the peptide's effect on brain-derived neurotrophic factor (BDNF) levels and its interaction with serotonergic pathways.
3. Neuroprotection
Research is being conducted on NA Selank Amidate's potential neuroprotective effects. Initial studies suggest that the peptide may help protect neurons from damage and death under various stress conditions. This neuroprotective quality could potentially benefit conditions involving neurodegeneration or brain injury.
4. Mood Regulation
Scientists are investigating NA Selank Amidate for its effects on mood regulation. The peptide appears to influence several neurotransmitter systems involved in mood control, including serotonin and dopamine pathways. This has led to research into its potential applications for mood disorders.
Secondary Research Applications
5. Cardiovascular Health
Early research is exploring the potential cardiovascular benefits of NA Selank Amidate. While this is not as extensively studied as its neuropsychiatric applications, there is interest in understanding how the peptide might affect cardiovascular function and health outcomes.
6. Peptic Ulcer Treatment
Some preliminary research suggests potential applications for NA Selank Amidate in treating peptic ulcers. The exact mechanisms behind this potential benefit are still being investigated.
7. Immunomodulation
Research has revealed that NA Selank Amidate may have immunomodulatory properties, particularly under stress conditions. Studies have shown that Selank can:
- Reduce concentrations of pro-inflammatory cytokines (IL-1β, IL-6, TGF-β1)
- Restore levels of anti-inflammatory cytokines (IL-4)
- Alter the Th1/Th2 cytokine balance in anxiety disorder patients
These findings suggest potential applications for conditions involving both immune dysregulation and stress or anxiety.
Adjunctive Therapy Applications
8. Enhancing Effectiveness of Anxiolytic Medications
An interesting area of research involves using NA Selank Amidate in combination with traditional anxiolytic medications. Studies on Selank have shown that it may potentiate the effects of benzodiazepines, potentially allowing for lower doses of these medications while maintaining therapeutic efficacy.
9. Mitigating Side Effects of Benzodiazepines
Research suggests that NA Selank Amidate might help reduce the common side effects associated with benzodiazepine use, including:
- Memory loss
- Attention deficits
- Drowsiness
- Asthenia
This potential benefit could make NA Selank Amidate valuable as an adjunctive therapy for patients requiring anxiolytic treatment.
Mechanism of Action
Understanding what NA Selank Amidate is researched for requires insight into its proposed mechanisms of action. Current research suggests it works through several pathways:
GABA System Interaction
NA Selank Amidate appears to act as a positive allosteric modulator of GABA signaling, similar to benzodiazepines but potentially without the same risk of dependence or tolerance development.
Serotonin Metabolism
Studies indicate that the peptide enhances serotonin metabolism in the brain stem, which may contribute to its anxiolytic and mood-regulating effects.
Enkephalin Regulation
Research suggests that NA Selank Amidate may block enkephalin-degrading enzymes, leading to increased enkephalin levels. Enkephalins are endogenous opioid peptides that can benefit mood and reduce stress.
BDNF Expression
The peptide has been shown to upregulate BDNF expression in the hippocampus, which may contribute to its cognitive-enhancing and neuroprotective effects.
References:
Kolomin, T., Shadrina, M., Slominsky, P., Limborska, S., & Myasoedov, N. (2013). A new generation of drugs: Synthetic peptides based on natural regulatory peptides. Neuroscience and Medicine, 4(04), 223-252. https://doi.org/10.4236/nm.2013.44035
Vyunova, T. V., Andreeva, L., Shevchenko, K., & Myasoedov, N. (2018). Peptide-based anxiolytics: The molecular aspects of heptapeptide Selank biological activity. Protein and Peptide Letters, 25(10), 914–923. https://doi.org/10.2174/0929866525666180925144642
Inozemtseva, L. S., Karpenko, E. A., Dolotov, O. V., Levitskaya, N. G., Kamensky, A. A., Andreeva, L. A., & Grivennikov, I. A. (2008). Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo. Doklady Biological Sciences, 421, 241–243. https://doi.org/10.1134/s0012496608040066
Disclaimer: This product is intended solely for laboratory research purposes. It is not suitable for consumption by humans, nor for medical, veterinary, or household purposes. Researchers should handle all peptides with care and adhere to strict safety guidelines during experiments. Only qualified professionals with appropriate expertise should manage and handle this product. The distributor, manufacturer, and seller of this product are not responsible for misuse or any resulting consequences. By accessing this product, you consent to comply with these terms and conditions.
