Product Specifications: Lyophilized Powder (>99% purity) in 3ml vial. *Requires Reconstitution ** Available for bulk custom order with 57 Cap/Crimp colors to choose from.
Application: Research peptide studied for anti-aging, longevity, exercise performance, cancer applications, metabolism, and cellular health.
Chemical Formula: C101H152N28O22S2
CAS Number: 1627580-64-6
Molecular Weight: ~2174.6 g/mol
Concentration: ≥99%
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a peptide encoded by mitochondrial DNA rather than nuclear DNA, distinguishing it from most other peptides in the human body. This unique origin has prompted significant scientific interest in its biological functions and potential therapeutic applications.
Primary Research Focus Areas
1. Metabolic Regulation
1.1 Mechanisms
MOTS-c has demonstrated significant regulatory effects on glucose and lipid metabolism pathways.
1.2 Target Conditions
Research focuses on metabolic disorders including:
- Type 2 diabetes
- Obesity
- Metabolic syndrome
2. Insulin Sensitivity
2.1 Blood Glucose Regulation
MOTS-c appears to enhance cellular responsiveness to insulin, which is crucial for:
- Maintaining normal blood sugar levels
- Glucose uptake by tissues
- Prevention of hyperglycemia
2.2 Prevention of Insulin Resistance
Studies suggest MOTS-c may help prevent the development of insulin resistance, a precursor to type 2 diabetes and other metabolic disorders.
3. Mitochondrial Function
3.1 Energy Homeostasis
As a mitochondrial-derived peptide, MOTS-c plays a role in regulating:
- Mitochondrial function
- Biogenesis of new mitochondria
- Cellular energy production and utilization
3.2 Cellular Metabolism
Research examines how MOTS-c influences the cellular powerhouses responsible for ATP production and overall metabolic health.
4. Aging and Longevity
4.1 Anti-Aging Properties
Investigations into MOTS-c focus on its potential to:
- Regulate cellular stress responses
- Promote healthy aging processes
- Mitigate age-related cellular decline
4.2 Longevity Pathways
Research explores MOTS-c's interaction with known longevity-associated cellular pathways, potentially offering insights into extending healthy lifespan.
5. Cancer Treatment
5.1 Therapeutic Applications
MOTS-c is being studied as a potential therapeutic agent for multiple cancer types, including:
- Breast cancer
- Lung cancer
- Colon cancer
5.2 Anti-Cancer Mechanisms
Ongoing research aims to understand how MOTS-c might influence cancer cell proliferation, metabolism, and survival pathways.
References:
Lee, C., Zeng, J., Drew, B. G., Sallam, T., Martin-Montalvo, A., Wan, J., Kim, S. J., Mehta, H., Hevener, A. L., de Cabo, R., & Cohen, P. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 21(3), 443-454. https://doi.org/10.1016/j.cmet.2015.02.009
Reynolds, J. C., Lai, R. W., Woodhead, J. S. T., Joly, J. H., Mitchell, C. J., Cameron-Smith, D., Lu, R., Cohen, P., Graham, N. A., Benayoun, B. A., Merry, T. L., & Lee, C. (2021). MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications, 12(1), 470. https://doi.org/10.1038/s41467-020-20790-0
Qin, Q., Delrio, S., Ghosh, S., Lee, C. J., Pan, H., Tontonoz, P., Lin, J. D., Yan, G., Chen, J., & Song, Z. (2023). Mitochondria-derived peptide MOTS-c: effects and mechanisms of action in human disease. Journal of Translational Medicine, 21(1), 258. https://doi.org/10.1186/s12967-023-03885-2
Disclaimer: This product is intended solely for laboratory research purposes. It is not suitable for consumption by humans, nor for medical, veterinary, or household purposes. Researchers should handle all peptides with care and adhere to strict safety guidelines during experiments. Only qualified professionals with appropriate expertise should manage and handle this product. The distributor, manufacturer, and seller of this product are not responsible for misuse or any resulting consequences. By accessing this product, you consent to comply with these terms and conditions.
