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Mazdutide 10mg

$93.00
SKU:
MAZD10
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Product Specifications: Lyophilized Powder (>99% purity) in 3ml vial. *Requires Reconstitution  ** Available for bulk custom order with 57 Cap/Crimp colors to choose from.

Application: Research peptide studied for GLP-1R functions in weight loss, diabetes management, cardiovascular health, and fatty liver disease recovery.

Chemical Formula: C210H322N46O67

CAS Number: 2259884-03-0

Molecular Weight: ~2563.1 g/mol

Concentration: ≥99%

Mazdutide functions as a dual agonist, simultaneously targeting:

  • Glucagon-like peptide-1 receptor (GLP-1R)
  • Glucagon receptor (GCGR)

This dual-targeting mechanism provides a unique pharmacological profile that appears to offer advantages over single-receptor targeting therapies in metabolic disease management.

Primary Research Applications

Type 2 Diabetes Mellitus

Mazdutide is being extensively researched for glycemic control in adults with type 2 diabetes. Clinical trials, including the DREAMS series (DREAMS-1, DREAMS-2), are evaluating its efficacy in this population. The compound has demonstrated promising results in:

  • Improving glycemic control
  • Potentially offering a new therapeutic option for diabetes management
  • Testing dosages of up to 6mg for type 2 diabetes applications

Obesity Management

A significant focus of mazdutide research is its application in chronic weight management for adults with overweight or obesity. Multiple clinical trials have demonstrated its effectiveness in this area:

  1. The GLORY-1 and GLORY-2 Phase 3 clinical studies are specifically investigating mazdutide in adults with overweight or obesity.
  2. In overweight adults, 24-week treatment with mazdutide (up to 6 mg) was found to be safe and led to clinically meaningful body weight reduction.
  3. One study reported that mazdutide dosed up to 6 mg achieved 12-week mean body weight loss of up to 6.4% in adults with overweight or obesity.
  4. Higher doses of 9mg are being studied specifically for obesity applications in the GLORY-1 Phase 3 trial.

Comorbid Conditions

Fatty Liver Disease

Recent research is expanding to investigate mazdutide's potential benefits in patients with fatty liver disease who are also overweight or obese. A head-to-head Phase 3 study (GLORY-3) comparing mazdutide versus semaglutide has been initiated in adults with overweight or obesity accompanied by fatty liver disease.

Clinical Trial Progress

Mazdutide's development pathway includes multiple phase 2 and phase 3 clinical trials:

  • Multiple Phase 3 studies are currently underway, including:
    • GLORY-1 and GLORY-2 for obesity management
    • DREAMS-1 and DREAMS-2 for type 2 diabetes
    • GLORY-3 comparing mazdutide to semaglutide in patients with fatty liver disease

References:

Zhang, B., Cheng, Z., Chen, J., Zhang, X., Liu, D., Jiang, H., Ma, G., Wang, X., Gan, S., Sun, J., Jin, P., Yi, J., Shi, B., Ma, J., Ye, S., Wang, G., Ji, L., & Gu, X. (2024). Efficacy and safety of mazdutide in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled phase 2 trial. Diabetes Care, 47(1), 160-168. https://doi.org/10.2337/dc23-1287 1

Ji, L., Gao, L., Jiang, H., Yang, J., Yu, L., Wen, J., Cai, C., Deng, H., Feng, L., Song, B., Ma, Q., & Qian, L. (2022). Safety and efficacy of a GLP-1 and glucagon receptor dual agonist mazdutide (IBI362) 9 mg and 10 mg in adults with overweight or obesity: A randomised, placebo-controlled, multiple-ascending-dose phase 1b trial. EClinicalMedicine, 54, Article 101691. https://doi.org/10.1016/j.eclinm.2022.101691 2

Ji, L., Jiang, H., Cheng, Z., Qiu, W., Liao, L., Zhang, Y., Li, X., Pang, S., Zhang, L., Chen, L., Yang, T., Li, Y., Qu, S., Wen, J., Gu, J., Ma, Q., & Qian, L. (2023). A phase 2 randomised controlled trial of mazdutide in overweight adults or adults with obesity. Nature Communications, 14, Article 8289. https://doi.org/10.1038/s41467-023-44067-4 3

Disclaimer: This product is intended solely for laboratory research purposes. It is not suitable for consumption by humans, nor for medical, veterinary, or household purposes. Researchers should handle all peptides with care and adhere to strict safety guidelines during experiments.  Only qualified professionals with appropriate expertise should manage and handle this product. The distributor, manufacturer, and seller of this product are not responsible for misuse or any resulting consequences. By accessing this product, you consent to comply with these terms and conditions.