Product Specifications: Lyophilized Powder (>99% purity) in 3ml vial. *Requires Reconstitution ** Available for bulk custom order with 57 Cap/Crimp colors to choose from.
Application: Research peptide studied for antimicrobial therapy, healing, tissue regeneration, cancer applications, anti-inflamation, respiratory improvements, and dermatological applications.
Chemical Formula: C205H340N60O53
CAS Number: 154947-66-7
Molecular Weight: ~4493.28 g/mol
Concentration: ≥99%
LL-37 is a cathelicidin-derived antimicrobial peptide that plays a crucial role in the innate immune system. Beyond its primary antimicrobial function, research has uncovered diverse biological activities that make it an appealing candidate for therapeutic development across multiple medical disciplines.
Research Applications of LL-37
- Antimicrobial Therapy
LL-37 demonstrates broad-spectrum antimicrobial activity against:
- Bacteria (both Gram-positive and Gram-negative)
- Viruses
- Fungi
This makes it particularly promising for addressing infections, especially in an era of increasing antimicrobial resistance. Its mechanism differs from conventional antibiotics, potentially offering alternatives for treatment-resistant infections.
- Wound Healing and Tissue Regeneration
Current research investigates LL-37's ability to accelerate wound healing through:
- Enhanced migration and proliferation of keratinocytes
- Increased fibroblast activity
- Improved endothelial cell function
These properties suggest applications in chronic wound management, surgical recovery, and regenerative medicine.
- Cancer Treatment
LL-37 exhibits anti-tumor properties through multiple mechanisms:
- Induction of apoptosis (programmed cell death)
- Inhibition of cancer cell growth
- Interference with tumor microenvironments
Research explores its potential as both a standalone treatment and as part of combination therapies for various cancer types.
- Inflammatory Disease Management
Research focuses on LL-37's dual immunomodulatory properties:
- Reduction of pro-inflammatory cytokines
- Promotion of anti-inflammatory cytokines
This balanced approach makes it interesting for treating chronic inflammatory conditions without completely suppressing immune responses.
- Neurological Disorders
Emerging research examines LL-37's neuroprotective effects:
- Reduction of oxidative stress in neural tissues
- Mitigation of neuroinflammation
- Potential benefits for neurodegenerative conditions
These properties suggest applications in conditions like Alzheimer's disease, Parkinson's disease, and stroke recovery.
- Cardiovascular Applications
LL-37's cardioprotective effects are being investigated for:
- Reducing vascular inflammation
- Improving cardiac function following injury
- Potential role in post-infarction recovery
- Prevention of atherosclerotic progression
- Respiratory Disease Treatment
Research explores LL-37's potential in respiratory medicine:
- Anti-inflammatory effects in lung tissue
- Applications in asthma management
- Treatment options for chronic obstructive pulmonary disease (COPD)
- Potential role in addressing respiratory infections
- Dermatological Applications
Skin-related research examines LL-37 for:
- Treatment of inflammatory skin conditions (psoriasis, atopic dermatitis)
- Management of acne through antimicrobial and anti-inflammatory effects
- Improvement of skin barrier function
- Potential cosmetic applications
References:
Wang, G., Mishra, B., & Zhang, J. (2016). Host defense antimicrobial peptides. Pharmaceuticals, 9(3), 1-15. doi: 10.3390/ph9030028
Zanetti, M. (2004). Cathelicidins, multifunctional peptides of the innate immunity. Journal of Leukocyte Biology, 75(1), 39-48. doi: 10.1189/jlb.0403147
Turner, J., Cho, Y., Dinh, N. N., Waring, A. J., & Lehrer, R. I. (1998). Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils. Antimicrobial Agents and Chemotherapy, 42(9), 2206-2214. doi: 10.1128/AAC.42.9.2206
Disclaimer: This product is intended solely for laboratory research purposes. It is not suitable for consumption by humans, nor for medical, veterinary, or household purposes. Researchers should handle all peptides with care and adhere to strict safety guidelines during experiments. Only qualified professionals with appropriate expertise should manage and handle this product. The distributor, manufacturer, and seller of this product are not responsible for misuse or any resulting consequences. By accessing this product, you consent to comply with these terms and conditions.
