Product Specifications: Lyophilized Powder (>99% purity) in 3ml vial. *Requires Reconstitution ** Available for bulk custom order with 57 Cap/Crimp colors to choose from.
Application: Research bioregulator studied for anti-aging and longevity, cellular health, anti-cancer, neurological benefits, cardiovascular health, pain management, liver function
Chemical Formula: C18H31N5O9
CAS Number: 195875-84-4
Molecular Weight: ~461.5 g/mol
Concentration: ≥99%
Livagen is a bioregulatory peptide that has garnered significant attention in the scientific community for its wide range of potential therapeutic applications. This short peptide, with the amino acid sequence Lys-Glu-Asp-Ala, is being investigated across multiple research domains due to its unique ability to influence cellular processes at the genetic and molecular levels. This report explores the diverse areas where Livagen is currently being researched, from liver health to immune modulation, and from anti-aging applications to neurological support.
Structural Overview and Mechanism of Action
Livagen is a short chain peptide bioregulator that directly influences DNA structure and function. As part of a class of bioactive peptides called cytokinins, Livagen is derived from the thymus gland and exhibits high flexibility and specificity in interacting with cellular receptors and other proteins.
Chromatin Modification and Gene Expression
The primary mechanism of action that distinguishes Livagen is its ability to modify chromatin structure through decondensation. Research suggests that Livagen can directly influence DNA by unpacking condensed chromatin, which allows for the activation of genes that may have been silenced due to the aging process. This mechanism is particularly significant for cellular rejuvenation and anti-aging research.
Studies comparing the effects of Livagen with other peptide bioregulators like Epitalon and Vilon on lymphocytes in aged cells have identified four distinct impacts of Livagen:
- Chromatin unpacking
- Decondensation induction
- Gene expression modification
- Ribosomal gene reactivation leading to increased protein synthesis 1
Primary Research Applications
1. Liver Disease Treatment
Livagen is prominently researched for its potential therapeutic applications in liver diseases and conditions. Studies indicate that it may promote liver health, reduce inflammation, and improve liver function.
2. Immune System Regulation and Activation
Livagen shows significant promise in immunology research. The peptide appears to stimulate immune system activity through its effects on lymphocytes, the main cells of the immune system. Research indicates that Livagen may enhance the production of key immune cells and signaling molecules essential for robust immune responses.
The peptide's impact on immune system lymphocytes has been the focus of most research, with findings suggesting that Livagen may help counteract diseases affecting the central nervous system, heart, gastrointestinal tract, and immune system via these cells.
3. Gastrointestinal Tract Protection
Current data points to an important role for Livagen in maintaining the integrity of the gastrointestinal mucosal barrier. Research suggests that Livagen may cause changes in mucosal nitric oxide and prostaglandin levels and increase vagal nerve signals to the gastrointestinal tract.
Investigations indicate that Livagen might alleviate symptoms of irritable bowel disease (IBD) and potentially aid in cases of infectious diarrhea through its gastroprotective properties. These benefits appear to be related to Livagen's ability to increase blood levels of enkephalin, which enhances the activation of mu and delta receptors important for gastrointestinal health.
4. Anti-Aging and Longevity
Livagen is being extensively researched for its anti-aging properties. The peptide's ability to decondense chromatin and reactivate genes that have been silenced due to aging positions it as a potential tool for slowing or reversing age-related cellular decline.
Professor Teimuraz Lezhava's work on chromatin modifications associated with cell aging documents how Livagen and similar bioregulatory peptides may influence the aging process by decondensing DNA. His findings suggest that these peptides may slow down or reverse age-related dysfunctions, such as immunological dysregulation and reduced protein synthesis 1.
5. Cardiovascular Health
Researchers have been investigating Livagen's potential effects on heart health, particularly in relation to hypertrophic cardiomyopathy (HCM) and atherosclerosis. Studies of HCM models point to chromatin dysregulation in lymphocytes as a pathogenic component of both HCM and atherosclerosis, suggesting that Livagen's chromatin-modifying properties could potentially enhance long-term cardiovascular outcomes.
6. Pain Management
Livagen is being studied for its effects on pain signaling mechanisms. Research indicates that Livagen may raise blood levels of endogenous analgesics by inhibiting enkephalin-degrading enzymes. This mechanism could have important implications for pain management, as enkephalins are short peptides that bind to opioid receptors and play crucial roles in pain relief, blood pressure regulation, and consciousness levels.
Studies have shown that Livagen and Epitalon inhibit enkephalin-degrading enzymes from human serum, with Livagen proving to be more efficient compared to well-known peptidase inhibitors.
7. Neurological and Cognitive Support
Another significant domain where Livagen is being researched is neurobiology. The central nervous system, particularly the brain, has limited capacity for regeneration, but peptides like Livagen are believed to support neuronal integrity and promote neuroprotection.
It has been hypothesized that Livagen may help modulate the activity of neurotrophic factors, which are proteins that support the growth and survival of neurons. Additionally, Livagen might contribute to neural regeneration by promoting synaptic plasticity, supporting cognitive flexibility and learning capacity.
8. Anti-Cancer Effects
Livagen is being investigated for its potential anti-cancer properties. Research suggests that it may inhibit the growth of cancer cells and induce apoptosis (programmed cell death) in certain types of cancer. While this area requires further research, initial findings indicate that Livagen could play a role in cancer treatment strategies.
9. Tissue Regeneration and Repair
One of the most intriguing prospects for Livagen research lies in its potential role in tissue regeneration. The peptide is thought to stimulate repair mechanisms in various tissues, including muscular, dermal, and organ tissues. This function may stem from its influence on cellular proliferation and differentiation.
Livagen may support tissue repair by modulating the activity of growth factors and cytokines vital to wound healing and tissue remodeling. It might also contribute to the restoration of extracellular matrix components, providing structural support for cells and aiding in tissue regeneration.
10. Cellular Health Maintenance
At the fundamental level, Livagen is being researched for its ability to support overall cellular health through multiple mechanisms:
- Supporting DNA repair processes
- Reducing oxidative stress
- Enhancing cellular resilience against environmental damage
- Potentially influencing telomerase activity, which plays a role in maintaining telomere length and preventing cellular senescence
- Stimulating DNA repair enzymes to maintain genomic integrity
References:
Kost, N. V., Sokolov, O. Iu., Gabaeva, M. V., Zolotarev, Iu. A., Malinin, V. V., & Khavinson, V. Kh. (2003). Effect of new peptide bioregulators livagen and epitalon on enkephalin-degrading enzymes in human serum. Izvestiia Akademii nauk. Seriia biologicheskaia, (4), 427–429.
Khavinson, V. Kh., Lezhava, T. A., Monaselidze, J. G., Dzhokhadze, T. A., Dvalishvili, N. A., Bablishvili, N. K., & Ryadnova, I. Yu. (2002). Effects of Livagen Peptide on Chromatin Activation in Lymphocytes from Old People. Bulletin of Experimental Biology and Medicine, 134, 389–392.
Trofimova, S. V., & Khavinson, V. Kh. (2021). Effect of peptide livagen on the activity of digestive enzymes of the gastrointestinal tract and non-digestive organs of rats of different ages. Cronicon, 1-7.
Disclaimer: This product is intended solely for laboratory research purposes. It is not suitable for consumption by humans, nor for medical, veterinary, or household purposes. Researchers should handle all peptides with care and adhere to strict safety guidelines during experiments. Only qualified professionals with appropriate expertise should manage and handle this product. The distributor, manufacturer, and seller of this product are not responsible for misuse or any resulting consequences. By accessing this product, you consent to comply with these terms and conditions.
