Product Specifications: Lyophilized Powder (>99% purity) in 3ml vial. *Requires Reconstitution ** Available for bulk custom order with 57 Cap/Crimp colors to choose from.
Application: Research peptide evaluated in muscle growth, fat reduction, cardiovascular health, memory enhancement, anti-aging, gastrointestinal benefits, sleep improvement. Anti-inflamation
Chemical Formula: Ipamorelin: C38H49N9O5. Tesamorelin: C221H366N72O67S
CAS Number: Ipamorelin: 170851-70-4 Tesamorelin: 218949-48-5
Molecular Weight: Ipamorelin: ~711.85 g/mol Tesamorelin: ~5135.86 g/mol
Concentration: ≥99%
Background on Individual Peptides
Tesamorelin
Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH), consisting of 44 amino acids with specific modifications that enhance its stability against enzymatic degradation. One notable modification is the introduction of a trans-3-hexenoic acid group at its C-terminus, often referred to as an omega-amino acid modification. This alteration is hypothesized to improve resistance to enzymatic breakdown, prolonging its functional lifespan in biological systems.
Tesamorelin's mechanism of action involves binding to GHRH receptors located in the hypothalamus and pituitary gland, thereby triggering the release of endogenous growth hormone (GH). Notably, tesamorelin has received FDA approval specifically for the treatment of HIV-associated lipodystrophy.
Ipamorelin
Ipamorelin is a synthetic pentapeptide that acts as a selective agonist for the ghrelin receptor, also known as the growth hormone secretagogue (GHS) receptor. This receptor is predominantly expressed in the pituitary gland, where its activation stimulates the release of GH. Ipamorelin exhibits high specificity for the GHS receptor with minimal interaction with other hormonal systems, reducing the likelihood of off-target effects.
Ipamorelin is recognized as the first selective growth hormone secretagogue, notable for not triggering the release of other hormones like cortisol, acetylcholine, prolactin, and aldosterone, unlike other GH-Secretagogues.
Synergistic Mechanism of Action
The combination of ipamorelin and tesamorelin creates a powerful synergistic effect on growth hormone secretion. This occurs because each peptide activates the growth hormone axis through distinct yet complementary mechanisms:
- Tesamorelin acts through GHRH receptors in the pituitary gland
- Ipamorelin activates the ghrelin receptor (GHS-R)
Together, these peptides provide multiple pathways to stimulate GH release, potentially resulting in greater effects than either peptide alone. This dual approach to GH stimulation has opened up numerous research avenues exploring various physiological systems and potential therapeutic applications.
Primary Research Applications
1. Enhanced Growth Hormone Production
The primary research focus of the ipamorelin and tesamorelin blend is its ability to stimulate natural growth hormone release. Studies suggest that when combined, these peptides produce a synergistic increase in GH levels that surpasses the effects of either peptide alone. This enhanced GH secretion follows a pulsatile pattern similar to the natural rhythm of the body, which is essential for regulating various physiological processes.
2. Body Composition Improvement
A major area of research involves the blend's effects on body composition:
- Visceral Fat Reduction: The blend is being studied for its ability to reduce visceral adipose tissue, particularly in models of HIV-associated lipodystrophy 1. Studies show that tesamorelin has demonstrated significant reductions in visceral fat.
- Muscle Preservation and Growth: Research suggests the combination may promote lean muscle mass preservation while simultaneously reducing fat, creating an improved overall body composition. This dual action makes the blend particularly interesting for research into conditions involving both fat accumulation and muscle wasting.
3. Metabolic Regulation
The ipamorelin and tesamorelin blend serves as a model for understanding metabolic regulation. Researchers are investigating:
- Insulin Sensitivity: How the blend affects insulin response and glucose metabolism
- Lipid Profiles: Effects on triglycerides, total cholesterol, and non-HDL cholesterol levels
- Metabolic Health: Potential improvements in overall metabolic function
Studies indicate that tesamorelin can lower triglyceride levels in the bloodstream, suggesting the blend may have significant impacts on lipid metabolism.
4. Cardiovascular Health
Research into cardiovascular effects has yielded several interesting findings:
- Reduced Blood Vessel Wall Thickness: Studies show tesamorelin can decrease carotid intima media thickness, potentially benefiting cardiovascular health.
- Cardiac Repair: Research in animal models suggests that growth hormone secretagogues may enhance post-myocardial infarction cardiac repair, with observed outcomes including reduced infarct size and improved cardiac ejection fraction.
- Lipid Profile Improvement: The blend shows potential to lower triglycerides, total cholesterol, and non-HDL cholesterol levels, suggesting broader impacts on cardiovascular function.
5. Cognitive Function Enhancement
Emerging research suggests that the ipamorelin and tesamorelin blend may have significant neurocognitive benefits:
- Memory Enhancement: Studies indicate that tesamorelin may enhance memory and cognitive abilities in both healthy older adults and individuals with mild cognitive impairment.
- Neuroprotection: Researchers are investigating potential neuroprotective properties that might benefit aging populations or those with cognitive decline.
6. Anti-Aging Applications
The decline in GH levels is a characteristic feature of aging, leading to various physiological changes. Research into the ipamorelin and tesamorelin blend examines:
- Age-Related Physiological Changes: How the peptides might modulate the physical effects of aging.
- Cellular Aging: Investigations into the role of GH in cellular lifecycles and how these peptides might influence age-related processes.
- Anti-Aging Benefits: Ipamorelin offers broader anti-aging and recovery benefits that complement tesamorelin's more targeted effects.
Additional Research Applications
7. Gastrointestinal Function
Research suggests the blend may have varying degrees of influence on the gastrointestinal tract:
- Gastric Emptying and Motility: Tesamorelin appears to enhance gastric emptying and gastrointestinal motility, while ipamorelin may stimulate gut motility upon binding to ghrelin receptors in the GI tract.
- Gut Barrier Integrity: Studies suggest the blend may support GI function by improving gut barrier integrity and mitigating intestinal inflammation.
- Tissue Repair: Research indicates potential contributions to tissue repair following gastrointestinal injury.
8. Sleep Quality Improvement
The blend is being researched for its potential effects on sleep patterns:
- Deep Sleep Enhancement: Studies suggest the combination may support improved sleep-wake cycles and enhanced deep sleep.
- Hormonal Regulation During Sleep: Research examines how the enhanced GH secretion affects hormonal patterns during rest periods.
9. Muscle-Wasting Disorders
Another significant research area involves potential applications for muscle-wasting conditions:
- Cachexia: The blend is being investigated for its potential to mitigate muscle loss in cachexia, a condition often associated with cancer and other chronic diseases.
- Sarcopenia: Research examines how the enhanced GH secretion and potential anabolic effects might benefit age-related muscle loss.
10. Inflammatory Modulation
The blend shows potential anti-inflammatory properties:
- Reduction in Inflammatory Markers: Research indicates tesamorelin can lower levels of C-reactive protein, a marker for inflammation.
- Anti-Inflammatory Mechanisms: Studies explore how the peptides' effects on GH might influence immune system regulation and inflammatory pathways.
References:
Sinha, D. K., Balasubramanian, A., Tatem, A. J., Rivera-Mirabal, J., Yu, J., Kovac, J., Pastuszak, A. W., & Lipshultz, L. I. (2020). Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Translational Andrology and Urology, 9(Suppl 2), S149-S159. https://doi.org/10.21037/tau.2019.11.30
Lake, J. E., LA, K., Erlandson, K. M., Adrian, S., Yenokyan, G., Scherzinger, A., Dubé, M. P., Stanley, T., Grinspoon, S., Falutz, J., Mamputu, J. C., Marsolais, C., McComsey, G. A., & Brown, T. T. (2021). Tesamorelin improves fat quality independent of changes in fat quantity. AIDS, 35(9), 1395-1402.
Disclaimer: This product is intended solely for laboratory research purposes. It is not suitable for consumption by humans, nor for medical, veterinary, or household purposes. Researchers should handle all peptides with care and adhere to strict safety guidelines during experiments. Only qualified professionals with appropriate expertise should manage and handle this product. The distributor, manufacturer, and seller of this product are not responsible for misuse or any resulting consequences. By accessing this product, you consent to comply with these terms and conditions.
