Product Specifications: Lyophilized Powder (>99% purity) in 3ml vial. *Requires Reconstitution ** Available for bulk custom order with 57 Cap/Crimp colors to choose from.
Application: Research peptide evaluated in anti-aging, hormone production and regulations, cancer treatment, fertility
Chemical Formula: C1105H1770N318O336S26
CAS Number: 9002-61-3
Molecular Weight: ~36,740 Daltons
Concentration: ≥99%
Human Chorionic Gonadotropin (HCG): Current Research Applications
Fertility and Reproductive Health Applications
Assisted Reproduction
HCG is being extensively researched for its applications in fertility treatments. It is used to stimulate ovulation in women with polycystic ovary syndrome (PCOS) and other ovulatory disorders. When administered to female animals (such as sows), HCG has been shown to improve conception rates, embryo implantation success, and overall reproductive performance.
Embryo Implantation and Pregnancy Maintenance
Research has demonstrated that HCG plays a crucial role in embryo implantation and maintenance of early pregnancy. The preimplantation blastocyst secretes HCG into the uterine space, which binds to LHCGR receptors on the decidual surface, preparing the uterine environment for implantation.
HCG increases the secretion of leukemia inhibitory factor (LIF) and decreases the secretion of interleukin-6 (IL-6) by endometrial cells, which are known to influence embryo implantation. It also promotes the differentiation of cytotrophoblasts into syncytiotrophoblasts, regulates prostaglandin synthesis, and affects the formation of cyclic AMP.
Male Fertility and Hormone Regulation
In men, HCG therapy is being researched for its potential to preserve spermatogenesis by maintaining intratesticular testosterone levels, particularly in men undergoing testosterone replacement therapy (TRT). Studies have shown that HCG monotherapy can significantly improve testosterone levels, with corresponding improvements in symptoms of hypogonadism.
Research indicates that relatively low-dose HCG can maintain intratesticular testosterone within the normal range in healthy men with gonadotropin suppression, with potential applications for male contraception and hormone replacement therapies.
Hormone Regulation and Balance
Testosterone Production
There is substantial research into HCG's effects on hormone regulation, particularly regarding testosterone production. Unequivocal evidence shows that HCG in males causes testosterone to be produced and released. This has applications for treating hypogonadism and other testosterone deficiency conditions.
Studies demonstrate that HCG-driven testosterone works synergistically with follicle-stimulating hormone (FSH) to increase sperm quantity, with FSH regulating structural genes responsible for cell development in spermatogenesis.
Hormetic Therapy
Recent research has investigated "HCG Hormetic Therapy" (HHT), which shows promising results in stimulating sex hormone production, reducing insulin resistance, and decreasing systemic inflammation. These findings suggest potential applications in metabolic and inflammatory disorders.
Cancer Treatment and Research
Tumor Marker Development
HCG is widely used as a tumor biomarker for certain cancers. It serves as an important marker for:
- Testicular cancer (both seminomatous and nonseminomatous)
- Gestational trophoblastic disease
- Ovarian germ cell tumors
- Potentially other malignancies
The utility of HCG as a biomarker extends to monitoring treatment response, with oncologists increasingly recognizing its value as a potentially low-cost marker for therapeutic monitoring.
Prognostic Indicator
Elevated expression of HCGβ in serum, urine, or tumor tissue has been identified as a strong indicator of adverse prognosis in many nontrophoblastic tumors. This makes HCG testing valuable not only for diagnosis but also for prognosis and treatment planning.
Novel Cancer Applications
Researchers are exploring new applications of HCG in cancer diagnostics, including its potential as a marker for parathyroid carcinoma and breast malignancies. Though some of these applications are still considered experimental, they represent promising areas of investigation.
Antitumor Effects
Interestingly, immunization to HCG in experimental models has shown antitumor effects, suggesting potential therapeutic applications beyond its use as a biomarker.
Regenerative Medicine and Tissue Repair
Angiogenic Properties
HCG is being researched for its angiogenic properties, which have implications for tissue repair and regenerative medicine. Studies show that HCG increases blood vessel formation and the migration and maturation of pericytes in various experimental models.
The hormone has a positive impact on the secretion of vascular endothelial growth factor (VEGF), a well-known molecule involved in angiogenesis. Recent research has shown that HCG regulates VEGF through the activation of nuclear factor kappa B (NF-κB) in luteal angiogenesis.
Tissue Protection
HCG has demonstrated protective effects on vascular endothelial cells against oxidative stress through inhibition of apoptosis, activation of cell survival signaling, and mitochondrial function retention. These properties make it a candidate for tissue protection strategies in regenerative medicine.
Fertility and Reproductive Health Applications
Assisted Reproduction
HCG is being extensively researched for its applications in fertility treatments. It is used to stimulate ovulation in women with polycystic ovary syndrome (PCOS) and other ovulatory disorders. When administered to female animals (such as sows), HCG has been shown to improve conception rates, embryo implantation success, and overall reproductive performance.
Embryo Implantation and Pregnancy Maintenance
Research has demonstrated that HCG plays a crucial role in embryo implantation and maintenance of early pregnancy. The preimplantation blastocyst secretes HCG into the uterine space, which binds to LHCGR receptors on the decidual surface, preparing the uterine environment for implantation.
HCG increases the secretion of leukemia inhibitory factor (LIF) and decreases the secretion of interleukin-6 (IL-6) by endometrial cells, which are known to influence embryo implantation. It also promotes the differentiation of cytotrophoblasts into syncytiotrophoblasts, regulates prostaglandin synthesis, and affects the formation of cyclic AMP.
Male Fertility and Hormone Regulation
In men, HCG therapy is being researched for its potential to preserve spermatogenesis by maintaining intratesticular testosterone levels, particularly in men undergoing testosterone replacement therapy (TRT). Studies have shown that HCG monotherapy can significantly improve testosterone levels, with corresponding improvements in symptoms of hypogonadism.
Research indicates that relatively low-dose HCG can maintain intratesticular testosterone within the normal range in healthy men with gonadotropin suppression, with potential applications for male contraception and hormone replacement therapies.
References:
Cole, L. A., & Butler, S. A. (2015). Human chorionic gonadotropin (hCG) (2nd ed.). Elsevier Academic Press. https://doi.org/10.1016/C2013-0-23135-9
Stenman, U. H., Tiitinen, A., Alfthan, H., & Valmu, L. (2006). The classification, functions and clinical use of different isoforms of HCG. Human Reproduction Update, 12(6), 769-784. https://doi.org/10.1093/humupd/dml029
Choi, J., & Smitz, J. (2014). Luteinizing hormone and human chorionic gonadotropin: Origins of difference. Molecular and Cellular Endocrinology, 383(1-2), 203-213. https://doi.org/10.1016/j.mce.2013.12.009
Disclaimer: This product is intended solely for laboratory research purposes. It is not suitable for consumption by humans, nor for medical, veterinary, or household purposes. Researchers should handle all peptides with care and adhere to strict safety guidelines during experiments. Only qualified professionals with appropriate expertise should manage and handle this product. The distributor, manufacturer, and seller of this product are not responsible for misuse or any resulting consequences. By accessing this product, you consent to comply with these terms and conditions.