Product Specifications: Lyophilized Powder (>99% purity) in 3ml vial. *Requires Reconstitution ** Available for bulk custom order with 57 Cap/Crimp colors to choose from.
Application: Research peptide evaluated in neurological enhancement, neurological health, neurological repair, anti-aging, sensory improvement, and nerve repair.
Chemical Formula: C27H44N4O5
CAS Number: 1401708-83-5
Molecular Weight: ~504.7 g/mol
Concentration: ≥99%
Research Applications
Neurological Enhancement and Repair
Dihexa shows promise in several areas of neurological enhancement:
- Creates new neural connections at a rate 7 times greater than BDNF (brain-derived neurotrophic factor)
- Promotes dendritic spine formation
- Enhances synaptic density
Alzheimer's Disease
Dihexa is primarily being researched as a potential treatment for Alzheimer's disease. Research has shown that it:
- Exhibits excellent antidementia activity in scopolamine and aged rat models
- Rescues cognitive impairment and recovers memory in APP/PS1 mouse models
- Increases synaptic connectivity, which is crucial for treating Alzheimer's disease
- Works by activating the PI3K/AKT signaling pathway in the brain
Parkinson's Disease
Significant research is being conducted on Dihexa's potential for:
- Preventing the development of Parkinson-like symptoms
- Improving motor function, as demonstrated by enhanced rope hang times and stride length in animal studies
Additional Medical Applications
Research has expanded to include:
- Protection of sensory cells:
- Protects lateral line hair cells from aminoglycoside ototoxicity
- Nerve repair:
- Shows promise as an adjunct therapy for promoting limb functional recovery after surgical nerve repair
- Traumatic conditions:
- Being investigated for stroke recovery
- Potential applications in traumatic brain injury treatment
Mechanism of Action
Dihexa functions through multiple pathways:
- Acts as a hepatocyte growth factor (HGF) mimetic
- Facilitates dimerization and availability at c-Met receptors
- Demonstrates anti-inflammatory and anti-apoptotic effects through the PI3K/AKT signaling pathway
References:
Sun et al. (2021) conducted research examining Dihexa's effects on cognitive function and memory in mouse models. Their study demonstrated that Dihexa successfully restored spatial learning and cognitive functions through the PI3K/AKT signaling pathway.
Weiss et al. (2021) investigated Dihexa's potential in promoting limb function recovery following nerve damage. Their experimental animal studies combined Dihexa with stem cells and other factors, demonstrating promising results for peripheral nerve repair.
Ho and Nation (2018) conducted a comprehensive systematic review examining the cognitive benefits of angiotensin IV and its analogs, including Dihexa.
Disclaimer: This product is intended solely for laboratory research purposes. It is not suitable for consumption by humans, nor for medical, veterinary, or household purposes. Researchers should handle all peptides with care and adhere to strict safety guidelines during experiments. Only qualified professionals with appropriate expertise should manage and handle this product. The distributor, manufacturer, and seller of this product are not responsible for misuse or any resulting consequences. By accessing this product, you consent to comply with these terms and conditions.
