Product Specifications: Lyophilized Powder (>99% purity) in 3ml vial. *Requires Reconstitution ** Available for bulk custom order with 57 Cap/Crimp colors to choose from.
Application: Research peptide evaluated in skeletal health, strength building, anti-aging, metabolism, tissue repair
Chemial Formula: C40H50N8O10
CAS Number: 77614-16-5
Molecular Weight: ~802.9 g/mol
Concentration: ≥99%
Dermorphin is a naturally occurring peptide researched primarily for pain management, particularly in postoperative and palliative care settings, with additional promising applications in anti-inflammatory treatment and wound healing. It has high potency and favorable side effect profile.
Primary Research Areas
Pain Management
The most extensively studied application of dermorphin is in pain management, particularly:
- Postoperative Pain Control
- Dermorphin shows superior efficacy compared to morphine when administered intrathecally
- It acts significantly longer than intrathecal morphine with fewer patients requiring additional analgesics
- Burn Pain Treatment
- Research demonstrates dermorphin's effectiveness in treating burn-related pain through peripheral μ-opioid receptor activation
- It helps reduce both evoked and spontaneous pain behaviors in burn injuries
- Palliative Care Applications
- Studies suggest potential use in palliative care settings due to its extended duration of action
- Single intrathecal administration has shown effective pain relief in palliative care patients
Anti-inflammatory Applications
Dermorphin demonstrates significant anti-inflammatory properties:
- Acts through the μ-opioid receptor to control inflammation
- Shows promise in treating various inflammatory conditions, including colon inflammation
- Research indicates potential benefits in reducing neuroinflammation
Specialized Medical Applications
- Chronic Pain Management
- Being investigated for treatment of chronic pain conditions
- Shows potential in managing neuropathic pain through peripheral mechanisms
- Wound Healing and Tissue Repair
- Studies indicate potential benefits in wound healing processes
- May contribute to tissue repair through anti-inflammatory effects
Advantages Over Conventional Treatments
- Potency and Selectivity
- Dermorphin acts as a highly potent and selective μ-opioid receptor agonist
- Shows greater potency than morphine in many applications
- Reduced Side Effects
- When administered peripherally, shows fewer central nervous system-related side effects
- May offer advantages over traditional opioids in terms of addiction potential
References:
Broccardo, M., Erspamer, V., & Falconieri-Erspamer, G. (1981). Dermorphin: A new potent opioid peptide from the skin of Phyllomedusa sauvagei. European Journal of Pharmacology, 71(2-3), 253-258.
Montecucchi, P. C., De Castiglione, R., Piani, S., Gozzini, L., & Erspamer, V. (1981). Amino acid composition and sequence of dermorphin, a novel opiate-like peptide from the skin of Phyllomedusa sauvagei. International Journal of Peptide and Protein Research, 17(3), 275-283.
Negri, L., & Improta, G. (1984). Dermorphin: A new opioid peptide from the skin of Phyllomedusa sauvagei. Journal of Pharmacy and Pharmacology, 36(10), 761-764.
Disclaimer: This product is intended solely for laboratory research purposes. It is not suitable for consumption by humans, nor for medical, veterinary, or household purposes. Researchers should handle all peptides with care and adhere to strict safety guidelines during experiments. Only qualified professionals with appropriate expertise should manage and handle this product. The distributor, manufacturer, and seller of this product are not responsible for misuse or any resulting consequences. By accessing this product, you consent to comply with these terms and conditions.
