Product Specifications: Lyophilized Powder (>99% purity) in 3ml vial. *Requires Reconstitution with Acetic Acid ** Available for bulk custom order with 57 Cap/Crimp colors to choose from.
Application: Research peptide evaluated in obesity and weight loss studies
Chemical Formula: C78H123N23O23S2
CAS Number: 221231-10-3
Molecular Weight: ~1815.1 g/mol
Concentration: ≥99%
AOD9604 is a synthetic peptide fragment derived from the C-terminus of human growth hormone (hGH), specifically corresponding to the Tyr-hGH 177-191 region. This fragment was isolated because it contains the lipolytic (fat-reducing) domain of hGH without incorporating the regions responsible for hGH's negative effects.
Primary Research Applications
1. Obesity Treatment
The predominant research focus for AOD9604 has been its potential as an anti-obesity therapeutic agent:
- Clinical trials have investigated its weight loss efficacy over 12-week periods
- Research has demonstrated competitive weight loss outcomes with accompanying health benefits at low doses
2. Fat Metabolism Modulation
AOD9604 shows specific activity on lipid metabolism:
- Early stage studies demonstrate positive effects on fat metabolism
- Research indicates it increases lipolytic sensitivity (enhanced fat breakdown)
- Studies in obese Zucker rats have examined its metabolic actions
3. Metabolic Profile Improvement
Beyond direct weight loss effects, research suggests broader metabolic benefits:
- Potential to improve overall metabolic profiles
- Associated health benefits beyond weight reduction have been observed
- Its effects appear to mimic the beneficial metabolic aspects of hGH while avoiding unwanted side effects
Scientific Significance
The scientific interest in AOD9604 stems from its unique properties:
- It selectively retains the fat-reducing activity of human growth hormone
- Unlike full hGH, it appears to avoid the negative effects associated with growth hormone administration
- It represents a targeted approach to metabolic modulation by isolating specific functional domains of hGH
Current Research Evolution
Research applications for AOD9604 have expanded beyond its initial obesity focus:
- The compound has transitioned from weight loss trials to cosmeceutical applications
- It continues to attract interest from health and wellness enthusiasts
- Its potential for muscle mass enhancement is being explored alongside fat reduction properties
References:
Ng, F. M., Sun, J., Sharma, L., Libinaka, R., Jiang, W. J., & Gianello, R. (n.d.). Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Journal of Endocrinology and Metabolism, 3(1-2), 7-15.
Heffernan, M., Summers, R. J., Thorburn, A., Ogru, E., Gianello, R., Jiang, W. J., & Ng, F. M. (2001). The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and β3-AR knock-out mice. Endocrinology, 142(12), 5182-5189.
Stier, H., Vos, E., & Kenley, D. (2013). Safety and tolerability of the hexadecapeptide AOD9604 in humans. Journal of Endocrinology and Metabolism, 3(1-2), 7-15.
Disclaimer: This product is intended solely for laboratory research purposes. It is not suitable for consumption by humans, nor for medical, veterinary, or household purposes. Researchers should handle all peptides with care and adhere to strict safety guidelines during experiments. Only qualified professionals with appropriate expertise should manage and handle this product. The distributor, manufacturer, and seller of this product are not responsible for misuse or any resulting consequences. By accessing this product, you consent to comply with these terms and conditions.
