Product Specifications: Lyophilized Powder (>99% purity) in 3ml vial. *Requires Reconstitution ** Available for bulk custom order with 57 Cap/Crimp colors to choose from.
Application: Research peptide evaluated in metabolism, weight loss, cancer, and neurological studies
Chemical Formula: C9H14N4O5
CAS Number: 2627-69-2
Molecular Weight: ~258.23 g/mol
Concentration: ≥99%
Primary Research Areas for AICAR
1. Metabolic Regulation and Energy Metabolism
AICAR (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside) functions as an AMP-activated protein kinase (AMPK) agonist, mimicking a low intracellular energy state. Research demonstrates that AICAR:
- Stimulates beneficial metabolic pathways
- Produces effects similar to exercise by activating AMPK
- Improves glucose tolerance and insulin sensitivity
2. Cancer Research Applications
As an AMPK activator, AICAR shows significant potential in oncology research:
- Inhibits proliferation of cancer cells through multiple mechanisms
- Suppresses mTOR complex 1 (mTORC1), a key regulator of cell growth
- Allows deeper investigation into cancer metabolic pathways
3. Skeletal Muscle Physiology
AICAR demonstrates effects on muscle metabolism and function:
- Being investigated for impacts on skeletal muscle growth
- Activates muscle energy metabolism pathways
- Mimics some exercise-like effects in muscle tissue
4. Neurological Effects and Cognitive Function
Research shows complex effects on brain function:
- Improves memory function and neurogenesis with short-term (one week) administration
- Shows different effects with prolonged treatment, potentially hampering brain function
5. Inflammation Modulation
AICAR demonstrates anti-inflammatory properties:
- Reduces high-fat diet-induced inflammation in adipose tissue
- This anti-inflammatory action correlates with metabolic improvements
6. Cellular Signaling Research
AICAR serves as an important research tool:
- Used as an agonist to study AMPK-dependent cellular pathways
- Helps elucidate complex signaling interactions, including feedback activation of mTORC2
- Activates the survival kinase Akt through mTORC2 stimulation
References:
Narkar, V. A., Downes, M., Yu, R. T., Embler, E., Wang, Y. X., Banayo, E., Mihaylova, M. M., Nelson, M. C., Zou, Y., Juguilon, H., Kang, H., Shaw, R. J., & Evans, R. M. (2008). AMPK and PPARδ agonists are exercise mimetics. Cell, 134(3), 405-415. https://doi.org/10.1016/j.cell.2008.06.051
Merrill, G. F., Kurth, E. J., Hardie, D. G., & Winder, W. W. (1997). AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. American Journal of Physiology-Endocrinology and Metabolism, 273(6), E1107-E1112. https://doi.org/10.1152/ajpendo.1997.273.6.E1107
Corton, J. M., Gillespie, J. G., Hawley, S. A., & Hardie, D. G. (1995). 5-Aminoimidazole-4-carboxamide ribonucleoside: A specific method for activating AMP-activated protein kinase in intact cells? European Journal of Biochemistry, 229(2), 558-565. https://doi.org/10.1111/j.1432-1033.1995.tb20498.x
Disclaimer: This product is intended solely for laboratory research purposes. It is not suitable for consumption by humans, nor for medical, veterinary, or household purposes. Researchers should handle all peptides with care and adhere to strict safety guidelines during experiments. Only qualified professionals with appropriate expertise should manage and handle this product. The distributor, manufacturer, and seller of this product are not responsible for misuse or any resulting consequences. By accessing this product, you consent to comply with these terms and conditions.
