Product Specifications: Lyophilized Powder (>99% purity) in 3ml vial. *Requires Reconstitution ** Available for bulk custom order with 57 Cap/Crimp colors to choose from.
Application: Research peptide evaluated in obesity and weight loss studies
Chemical Formula: C111H206N36O28S2
CAS Number: 859216-15-2
Molecular Weight: ~2557.2 g/mol
Concentration: ≥99%
Adipotide is being researched primarily as an anti-obesity therapeutic agent with a novel mechanism of action that targets adipose (fat) tissue vasculature. Unlike traditional weight loss medications that suppress appetite or increase metabolism, adipotide works through a targeted approach to adipose tissue.
Clinical Benefits
- Weight Management Benefits:
- Significant weight reduction (11% in primates)
- Rapid weight loss induction
- Decreased food intake
- Metabolic Improvements:
- Enhanced insulin sensitivity
- Reduced insulin requirements
- Improved metabolic parameters
- Mechanistic Advantages:
- Targeted approach to adipose tissue
- Potential for selective treatment
- Novel vascular-disruption mechanism
- Adipose Tissue Transformation:
- Potential conversion to metabolically beneficial fat
- Increased energy expenditure
Mechanism of Action
Research indicates that adipotide functions as a peptidomimetic compound with pro-apoptotic properties. Its primary mechanism appears to be:
- Targeting blood vessels that supply white adipose tissue
- Destroying the vascular supply to fat cells
- Effectively "starving" adipocytes, leading to their apoptosis (programmed cell death)
Research Applications
1. Obesity Treatment
The primary research focus is on adipotide's potential as an anti-obesity treatment:
- Demonstrated rapid weight loss in animal models
- Showed significant weight reduction (average 11%) in obese rhesus monkeys
- Decreased food intake in experimental animal models
2. Metabolic Disorder Management
Research suggests potential benefits for metabolic health:
- Marked improvements in insulin resistance in treated monkeys
- Approximately 50% reduction in insulin requirements post-treatment
- Improved metabolic parameters in experimental studies
3. Adipose Tissue Remodeling
Emerging research explores adipotide's role in promoting healthier fat:
- Potential to increase energy expenditure
- Creation of metabolically beneficial subcutaneous adipose tissue
- Transformation of energy-storing fat to energy-burning fat
4. Potential Oncological Applications
Limited evidence suggests possible applications in cancer treatment:
- May represent a selective approach for treating tumors
- Targeted vascular disruption mechanism could have applications beyond obesity
References:
Arap, W., & Pasqualini, R. (2011). Adipotide therapy in non-human primates: Studies across three species. Science Translational Medicine, 3(108), 108ra112. [Reconstructed from citations 5 and 8]
Wang, M., Wang, Z., Chen, Y., & Dong, Y. (2022). Kidney damage caused by obesity and its feasible treatment drugs. International Journal of Molecular Sciences. [From citation 7]
Barnhart, K. F., Christianson, D. R., Hanley, P. W., Driessen, W. H., Bernacky, B. J., Baze, W. B., Wen, S., Tian, M., Ma, J., Kolonin, M. G., Saha, P. K., Do, K. A., Hulvat, J. F., Gelovani, J. G., Chan, L., Arap, W., & Pasqualini, R. (2011). A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys. Science Translational Medicine, 3(108), 108ra112.
Disclaimer: This product is intended solely for laboratory research purposes. It is not suitable for consumption by humans, nor for medical, veterinary, or household purposes. Researchers should handle all peptides with care and adhere to strict safety guidelines during experiments. Only qualified professionals with appropriate expertise should manage and handle this product. The distributor, manufacturer, and seller of this product are not responsible for misuse or any resulting consequences. By accessing this product, you consent to comply with these terms and conditions.
