Product Specifications: Clear liquid of 0.6% Acetic Acid in bacteriostatic water in 3ml vial. ** Available for bulk custom order with 57 Cap/Crimp colors to choose from.
Application: For reconstitution of peptides which are initially water insoluble.
Chemical Formula: CH₃COOH
CAS Number: 64-19-7
Molecular Weight: ~ 60.05 g/mol, Molarity = (0.6 g / 60.05 g/mol) × (100 mL / 1000 mL/L) = 0.1 M
Concentration: 0.6%
Peptides Recommended for Acetic Acid Reconstitution – IGF-1 derivitaves, AOD 9604, Retatrutide, otherwise water-insoluble peptides
- Hydrophobic peptides
- 50% aqueous acetic acid solution is specifically recommended for hydrophobic peptides
- Peptides with solubility issues
- Acetic acid is better for peptides prone to solubility issues
- Used for peptides with low solubility in water
- Recommended when peptides are insoluble in other solutions (10% v/v concentration)
- Peptides with specific pH sensitivities
- Peptides prone to degradation in neutral pH
- Basic peptides with isoelectric point (PI) < 7
- Peptides with positive overall charge
- If water dissolution fails, 10% to 30% acetic acid solution is recommended
Acetic acid plays several important roles in peptide chemistry and proteomics:
- Peptide Reconstitution and Stability
- Used as an alternative to bacteriostatic water with 0.9% benzyl alcohol for reconstituting peptides, with questions about whether it results in longer-lasting peptides
- Peptide Synthesis and Modification
- Used with hydrogen bromide for removing carbobenzoxy groups and benzyl esters from peptide derivatives during peptide synthesis
- Proteomics Enhancement
- Improves proteomic coverage on sub-nanogram injections of peptides
- Functions as a superior ion pairing modifier for sub-nanogram and single cell proteomics
- Increases relative signal that can be used to obtain more scans in proteomics analysis
Disclaimer: This product is intended solely for laboratory research purposes. It is not suitable for consumption by humans, nor for medical, veterinary, or household purposes. Researchers should handle all peptides with care and adhere to strict safety guidelines during experiments. Only qualified professionals with appropriate expertise should manage and handle this product. The distributor, manufacturer, and seller of this product are not responsible for misuse or any resulting consequences. By accessing this product, you consent to comply with these terms and conditions.
